Carole’s Accomplishments

2016 in Review

  • Epidemiologic research:
    • Disease area review on hidradenitis suppurativa
    • Disease area review on overactive bladder
    • Clinical study design and analysis plan for a prospective case-control study to assess patient-reported outcomes associated with fistula placement and patency in hemodialysis
    • Research protocol for a longitudinal observational registry study to evaluate clinical outcomes associated with next-generation genomic sequencing for advanced solid and hematologic malignancies
    • Development of patient and disease profiles associated with increased cardiovascular events attributed to non-steroidal anti-inflammatory drugs and cyclooxygenase-2 selective inhibitors for acute and chronic pain
  • Health economics and outcomes research:
    • Market access value dossier on therapeutic options for overactive bladder
    • Global value dossier on advanced and metastatic renal cell carcinoma
    • Costs and healthcare utilization associated with oral tyrosine kinase inhibitor therapy for advanced non-small cell lung cancer
  • Strategic consulting and publication planning:
    • Scientific platform and publication plan for a small-molecule multitargeted receptor tyrosine kinase inhibitor for metastatic renal cell carcinoma
    • Benefit-risk analysis and new drug briefing package for the switch from prescription to over-the-counter emergency contraception
    • Strategic platform and publication plan for a targeted cytotoxic peptide conjugate for advanced, metastatic endometrial cancer
  • 17 manuscripts for peer-reviewed journals:
    • Healthcare costs and resource utilization associated with tyrosine kinase inhibitor treatment of advanced non-small cell lung cancer
    • Medical therapy for gram-positive acute bacterial skin and skin structure infections (2)
    • Global prevalence and management of asthma (2)
    • Nonopioid management of chronic pain (2)
    • Prevention of opioid overdose and poisoning
    • Safety and efficacy of immunotherapy for metastatic renal cell carcinoma
    • Luteinizing hormone-releasing hormone for the inhibition of human cancer
    • Incidence, risk factors, and prevention of non-ventilator associated hospital-acquired pneumonia (2)
    • Treatment patterns and direct medical costs associated with phosphodiesterase type 5 inhibitor treatment of pulmonary hypertension
    • Comparative analysis of intervention for the prevention of migraine
    • Treatment adherence in chronic obstructive pulmonary disease
    • Incidence, risk factors, and prevention of patient-handling injuries to healthcare workers
    • Surveillance versus monitoring in patient care
  • 39 interactive, online educational articles for clinicians on atrial fibrillation, attention deficit hyperactivity disorder, binge eating disorder, fractures and falls, follicular lymphoma, gout, osteoporosis, osteoarthritis, psoriasis, psoriatic arthritis, and rheumatoid arthritis

Selected 2015 Highlights

  • Epidemiological research, strategic consulting, and publication planning on cardiovascular events associated with NSAIDs and COX-2 inhibitors, NAFLD and NASH, oncology, safe patient handling, urology, and vasomotor symptoms
  • Interactive training programs for clinical sales specialists and clinicians
  • 12 manuscripts for peer-reviewed journals
  • 14 peer-reviewed articles for an online accredited medical news service
  • 4 continuing medical education programs

2015 in Review

  • 16 epidemiology, health economics and outcomes research, publication planning, or product launch projects:
    • Endometrial cancer (2)
    • Non-small cell lung cancer (5)
    • BRAF V600E mutation-positive metastatic melanoma (1)
    • Relapsed/refractory multiple myeloma (1)
    • Nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (2)
    • Overactive bladder (2)
    • Patient handling injuries (3)
  • 12 manuscripts for peer-reviewed journals:
    • Medical therapy for gram-positive acute bacterial skin and skin structure infections
    • Inhaler training, confidence, and adherence in chronic obstructive pulmonary disease
    • Impact of dementia on health care resource utilization and quality of life
    • Diabetes education effect on treatment intensification and persistence
    • Systematic review of diabetes self-management education on glycemic control
    • Management of pediatric hereditary angioedema
    • The role of long-term prophylaxis in hereditary angioedema
    • Unintentional hypothermia in the perioperative setting
    • Risk factors and prevention of patient-handling injuries
    • Role of nurse surveillance in the prevention of adverse events
    • Burden of pediatric respiratory syncytial virus
    • Medical therapy for S. aureus infections
  • 14 interactive educational articles for clinicians on atrial fibrillation, bipolar disorder, breast cancer, gout, HIV, osteoporosis, prostate cancer, stroke, and work-related medical conditions affected health care professionals
  • 6 interactive training programs for clinical sales specialists, clinicians, and medical writers:
    • Basic concepts in biostatistics (eg. measures of central tendency and variation, tabular and graphic data presentation)
    • Intermediate biostatistics (eg. analysis of variance, association and correlation, multivariate analysis of variance
    • Advanced biostatistics (eg, analysis of covariance, linear and logistic regression, survival analysis)
    • Basics of epidemiology
    • Basics of health economics and outcomes research
  • 4 continuing medical education programs and materials:
      Inflammatory bowel disease

    • Hormone therapy for management of menopausal symptoms
    • Patient-clinician dialogue about obesity
    • Optimal management of atrial fibrillation
  • Posters, abstracts, or slide sets for professional conferences and congresses:
    • Cardiometabolic effects of medical therapy for NAFLD and NASH for 2015 European Fatty Liver Disease Conference
    • Presentation summaries for the 57th American Society of Hematology Annual Meeting
    • Evidence-based protocol for lateral patient transfer to reduce health care worker injury for 2015 Safe Patient Handling and Mobility meeting
    • Slide set and moderator’s guide on timely management of menopause

Selected 2014 Highlights

  • Epidemiological research, strategic consulting, and publication planning in oncology, NAFLD and NASH, diabetes, and autism
  • Development of sales training programs in acute coronary syndrome, chronic wound care, hypertension, overactive bladder, and smoking cessation
  • 10 manuscripts for peer-reviewed journals
  • 17 peer-reviewed articles for an online accredited medical news service
  • 8 continuing medical education programs in attention deficit/hyperactivity disorder, chronic wound care, diabetes, health care reform, multiple sclerosis, obesity, oncology, and adolescent vaccinations

2014 in Review

  • 5 epidemiology, health economics and outcomes research, publication planning, or product launch projects:
      Cardiovascular effects of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
  • Dual-acting angiotensin receptor-neprilysin inhibitor
  • Endoscopic intervention for type 2 diabetes
  • First-in-class treatment for autism
  • Non-Hodgkin lymphoma
  • 10 manuscripts for peer-reviewed journals on asthma, bacteremia, diabetes, hypercholesterolemia, lipid-lowering therapies, methicillin-resistant staph aureus infection, respiratory syncytial virus, and diabetes self-management education
  • 5 training programs for pharmaceutical sales specialists and medical science liaisons:
    • Acute coronary syndrome
    • Current and emerging antihypertensive agents
    • Strategies for optimal care of chronic wounds
    • Pharmacologic interventions for diverse populations with overactive bladder
    • Pharmacologic interventions for smoking cessation
  • 8 continuing medical education programs and materials:
    • Pediatric and adult attention deficit/hyperactivity disorder for primary care providers
    • Case-based module on methods of debridement for chronic wounds
    • Evidence-based management of type 2 diabetes mellitus, including strategies for treatment intensification
    • Clinical implications of health care reform and the Affordable Care Act
    • Current and novel treatments for multiple sclerosis
    • Current and emerging therapies for non-Hodgkin lymphoma
    • Optimal strategies for management of obesity in primary care
    • Strategies to improve adherence to guidelines for adolescent vaccinations
  • 13 interactive educational articles for clinicians on ankylosing spondylitis, atrial fibrillation, BRCA1 and BRCA2, chronic obstructive pulmonary disease (3), multiple myeloma, ST-elevation myocardial infarction, osteoporosis (2), psoriasis and psoriatic arthritis (2), and unstable angina
  • 1 white paper on duodenal mucosal resurfacing
  • 4 consumer health education programs:
    • Attention deficit/hyperactivity disorder
    • Type 2 diabetes
    • Health care reform
    • Mesothelioma
  • Selected 2013 Highlights

    • Epidemiological research, strategic planning, and publication planning in cardiovascular disease, diabetes, and oncology
    • Development of training programs in acute coronary syndrome, oncology, psychiatric disorders, and renal disease
    • Completion of a systematic review of 130 publications to evaluate the impact of diabetes self-management education on clinical outcomes
    • 13 manuscripts for peer-reviewed journals
    • Author for a 7-chapter disease digest on schizophrenia
    • Continuing medical education programs in cardiovascular disease, diabetes, oncology, neurology, psychiatry, and women’s health

    2013 in Review

    • 7 epidemiology, health economics and outcomes research, publication planning, or product launch projects:
      • Acute coronary syndrome
      • Aortic stenosis
      • Clostridium difficile
      • Diabetes
      • Glioblastoma multiforme
      • Malignant melanoma
      • Patient-centered care for diabetes
    • 13 manuscripts for peer-reviewed journals on chronic obstructive pulmonary disease, diabetes, diabetes self-management education, influenza, meningitis, mitral valve regurgitation, pediatric vaccinations, schizophrenia, transcatheter aortic valve replacement, and worksite healthcare reform
    • 3 training programs for pharmaceutical sales specialists and medical science liaisons:
      • Acute coronary syndrome
      • Autosomal dominant polycystic kidney disease
      • Metastatic melanoma
    • 17 continuing medical education programs and materials:
      • Alzheimer’s disease and dementia
      • Breast cancer
      • Metastatic colorectal cancer
      • Type 2 diabetes mellitus
      • Endometriosis
      • Fibromyalgia
      • HIV/AIDS
      • Hypertension
      • Irritable bowel syndrome with constipation
      • Ischemic stroke
      • Major depressive disorder
      • Multiple myeloma
      • Multiple sclerosis
      • Musculoskeletal disorders associated with menopause
      • Rheumatoid arthritis
      • Schizophrenia
      • Sexually transmitted infections
    • 16 interactive educational articles for clinicians on atrial fibrillation, chronic pain impact and management, cystic fibrosis and nutritional management, ischemic stroke and biomarkers associated with prognosis, ischemic stroke rehabilitation with robotics, pancreatic exocrine insufficiency management, pulmonary embolism prophylaxis, and rheumatoid arthritis
    • 1 grant application on transcatheter aortic valve replacement
    • 3 white papers addressing ambulatory and continuous glucose monitoring in diabetes
  • Selected 2012 Highlights

    • Analysis of the epidemiologic burden imposed by Clostridium difficile, various cancers, women’s health, and diabetes
    • Health economics and outcomes research projects on Clostridium difficile, diabetes, various cancers, and women’s health
    • Development of 5 online training programs for clinical sales specialists and medical science liaisons addressing topics in oncology, psychiatric disorders, and women’s health
    • Quantitative and qualitative competitive strategic analyses for various cancers
    • Continuing medical education programs in oncology, neurology, psychiatry, and women’s health

    2012 in Review

    • 10 manuscripts for peer-reviewed journals on hematologic cancers, colorectal cancer, prostate cancer, worksite health promotion, healthcare reform, and clinical decision support systems
    • 11 continuing medical education programs and materials addressing:
      • Atrial fibrillation
      • Contraception
      • Diabetes
      • Endometriosis
      • Fibromyalgia
      • Health risk communication
      • Metastatic melanoma
      • Multiple sclerosis
      • Musculoskeletal disorders associated with menopause
      • Pediatric medication safety
      • Renal cell carcinoma
    • 8 epidemiology and health economics and outcomes research projects addressing:
      • Clostridium difficile
      • Colorectal cancer
      • Diabetes
      • Endometriosis
      • Malignant melanoma
      • Prostate cancer
      • Renal cell carcinoma
      • Uterine fibroids
    • 5 training programs for pharmaceutical sales specialists and medical science liaisons addressing:
      • Colorectal cancer
      • Endometriosis
      • Gastrointestinal stromal tumors
      • Melanoma
      • Schizophrenia
    • 3 competitive strategic analyses addressing emerging therapies for:
      • Hormone-refractory prostate cancer
      • Metastatic colorectal cancer
      • Gastrointestinal stromal tumors
    • 3 white papers addressing alarm fatigue, innovations in orthopedic surgical techniques, and new pharmacologic agents for neurologic diseases
    • 6 online articles for healthcare practitioners addressing chronic pain and Parkinson disease
    • 6 consumer health education programs addressing:
      • Atrial fibrillation
      • Contraception
      • Fibromyalgia
      • Metastatic melanoma
      • Pediatric medication safety
      • Renal cell carcinoma

    Selected 2011 Highlights

    • Review of the epidemiologic burden, risk factors, therapeutic options, and prognosis for various solid and non-solid tumors to support 5 applications for submission to the European Medicines Agency and the US Food and Drug Administration
    • Medical expert supporting the launch of 2 new interventions approved for the treatment of ischemic stroke and hypercholesterolemia
    • Medical expert supporting the launch of a new pharmacologic agent approved for basal cell carcinoma
    • Quantitative and qualitative competitive strategic analyses for the treatment of diverse solid and non-solid malignancies
    • Evaluation of the incidence and severity of chemotherapy-induced peripheral neuropathy associated with various oncolytic therapies
    • Epidemiologic coordinator and statistician for a prospective evaluation of different treatments for hereditary angioedema including assessment of efficacy, safety, impact on patients’ quality of life

    2011 in Review

    • 18 manuscripts for peer-reviewed journals on various topics including cardiovascular disease, hepatitis B, osteoarthritis, clinical decision support systems, health promotion, and oncology
    • 10 epidemiologic analyses and statistical support for:
      • Acute myelogenous leukemia
      • Breast cancer
      • Central nervous system metastases
      • Chronic lymphocytic leukemia
      • Gastric cancer
      • Hepatocellular cancer
      • Hereditary angioedema
      • Multiple myeloma
      • Non-Hodgkin lymphoma
      • Non-small cell lung cancer
    • 10 publication plans and strategic competitive analyses for:
      • Acute myelogenous leukemia
      • Basal cell carcinoma
      • Chemotherapy-induced neuropathy
      • Diffuse large B cell lymphoma
      • Endometriosis
      • Glioblastoma multiforme
      • Ovarian cancer
      • Pediatric solid tumors
      • Triple negative breast cancer
      • Uterine myomas
    • 5 training programs for clinical sales specialists to support launch of new pharmaceutical products including 3 oncology and 2 cardiovascular products
    • 5 continuing medical education programs and materials including
      • Live presentation and a webinar on the incidence, symptoms, diagnosis, and management of depression in women
      • Best practices guide for the treatment of metastatic melanoma
      • Best practices guide for the treatment of renal cell carcinoma
      • Live presentation on the role of recombinant interleukin-2 in cancer immunotherapy
      • Adult health promotion and risk reduction program for nurse practitioners
      • Performance improvement intervention to improve the care of patients with atrial fibrillation
    • 4 white papers on medical devices for use by sales personnel
    • 4 continuing medical education proposals
    • 2 consumer health education programs addressing:
      • Adult health promotion and risk reduction
      • Atrial fibrillation
    Download a summary of Carole’s projects and key accomplishments from 2014-2016. 

    Carole Alison Chrvala, PhD
    President and owner of Health Matters, Inc.